Two sides looking to distance themselves from the dreaded wooden spoon go head to head in what should be a closely contested encounter on Monday night.
Elijah Taylor will be sidelined for four to six weeks with a fractured hand suffered during Penrith's loss to St George Illawarra.
Penrith prop Brent Kite announced his retirement from the game on Friday, officially bringing to an end a stellar 313 game NRL career.
St George Illawarra kept their finals hopes alive while extinguishing any slim chance the Panthers may have had, winning in an arm-wrestle of a game.
The Dragons have overcome an injury-ravaged Panthers outfit in a tight affair at WIN Stadium on Thursday night.
Penrith star Matt Moylan has conceded he won't play again this NRL season due to a foot injury suffered in May.
Still bruised by last week's heavy defeat against Brisbane, the Dragons will have to defy their recent history against Penrith if they are to prevail here.
Penrith's versatile star, a young Rabbitoh makes a strong return, and the fullback about to smash through the 5000 run-metre barrier. Key stats from Round 23.
A shock immediate retirement headlined the Panthers' five-game losing-streak ending win over the Warriors, whose finals hopes now hang in the balance.
It was an innocuous bump to the head at the captain's run before the Panthers' 24-10 win over the Warriors that proved the final straw for Nigel Plum.