A dominant second-half performance led by North Queensland hooker Jake Granville has helped the Cowboys to their biggest ever win over the Eels.
Cronulla staked their NRL Telstra Premiership finals claims with a hard-fought win over Canterbury at Belmore Sports Ground.
Canberra kept their NRL Telstra Premiership finals hopes alive while putting in dent in Penrith's top eight aspirations in an exciting and high-scoring game.
The Rabbitohs put on a clinic against a poor Knights side at ANZ Stadium on Saturday, with Greg Inglis and Dylan Walker scoring hat-tricks in a thrashing.
Shaun Johnson suffered a season-ending ankle injury as the Sea Eagles kept their faint finals hopes alive with a a 32-12 victory over the Warriors in Auckland.
Four second-half tries, including a double to young winger Brendan Elliot, has helped the Roosters to a comfortable win over Wests Tigers on Friday night.
The Broncos have held the Titans to nil and extended their winning run to eight with a resounding victory at Suncorp Stadium on Friday night.
Two sides on the verge of the top eight go head to head in a clash that could make or break their season this Sunday afternoon.
The Eels have been hit hard on the injury front and the Cowboys will be keen to run up a big score at home to show off their premiership credentials here.
The number of interchanges will be reduced to eight and a shot clock will be introduced to reduce stoppages in landmark changes to the NRL Telstra Premiership.