The Sea Eagles return to Brookvale Oval for the first time in a month to take on the cellar-dwelling Newcastle Knights.
When the Eels and Tigers meet, you can almost guarantee entertainment, and this clash should be no different with plenty of points in both sides.
Two teams aiming to play their way out of a form slump go head-to-head, with the Roosters enjoying home ground advantage and Brisbane with more to play for.
A spot in the NRL Telstra Premiership top eight could be up for grabs when the Warriors host the Panthers at Mt Smart Stadium on Saturday.
Canterbury and St George Illawarra will both be aiming to make amends after being embarrassed in Round 20 of the NRL Telstra Premiership.
Manly have extended their winning run to three, keeping their finals hopes alive with an important victory over South Sydney at Allianz Stadium on Monday night.
Mitch Moses was the star as the Wests Tigers shrugged off another week of drama to comfortably dispose of the Dragons at ANZ Stadium on Sunday afternoon.
Cronulla have improved their winning streak to 15, running in eight tries to deal an injury-ravaged Newcastle side another loss on Sunday afternoon.
The Melbourne Storm were at their efficient best on Saturday night, rolling past the Roosters 26-10 to remain in the race for the NRL minor premiership.
The Titans have guaranteed their place in the top eight for a further week and officially brought Parramatta's brave season of resistance to an end.