Last year's premiers take on the next-to-last placed Knights in their Round 5 Telstra Premiership clash at Southern Cross Group Stadium on Saturday.
The Rabbitohs travel north to face a Cowboys side that welcome back two of their best in Jason Taumalolo and Lachlan Coote on Friday night.
Two of the best performers from Round 4 renew hostilities in Sydney's battle of the beaches.
The Broncos face their first trip to ANZ Stadium in 2017, travelling to face the Canterbury Bulldogs in a match-up with big implications for both sides.
Outstanding performances from Paul Vaughan and Josh Dugan have guided St George Illawarra to a comfortable victory over the Warriors.
Melbourne have stormed back from an early 14-point deficit to extend their unbeaten start to the year with a gutsy win over the Wests Tigers.
Rampaging back-rower Coen Hess has shrugged aside the absence of Jason Taumalolo and Matt Scott to seal the Cowboys' 32-26 win over the Titans on Saturday.
James Segeyaro returned to the NRL as the Cronulla Sharks ground their way to a 20-6 win over an error-prone Parramatta Eels side at ANZ Stadium on Saturday.
A red-hot Manly side exploded out of the blocks to hand the Bulldogs a 36-0 defeat at Lottoland on Saturday afternoon.
A field goal from Broncos winger Jordan Kahu has proved the difference as Brisbane edged Canberra by one point at Suncorp Stadium on Friday night.