Melbourne will play Monday night's game without their captain, champion fullback, two leading try-scorers and key playmaker. But the Eels have their own issues.
The Eels have been competitive but a number of narrow losses has made it difficult for the Parramatta side to launch a real challenge on the top eight.
Dejected Eels coach Brad Arthur says Parramatta are currently a "70-minute team" after yet another late-game brain fade cost them a win.
It was a 24-point comeback that simply had to be seen to be believed, here are five talking points about a game that will go down as a classic for the ages.
Parramatta's coach and players didn't mince their words after coughing up a 24-point lead in their loss to North Queensland on Monday night.
North Queensland second-row forward Gavin Cooper scored a hat-trick of tries in six second-half minutes as the Cowboys overran Parramatta at Pirtek Stadium.
Eels forward David Gower says the club owes it to their fans to put in a big effort at home after three straight losses at one-time fortress, Pirtek Stadium.
Parramatta Eels are hoping to raise awareness and funds to combat homelessness with the help of Parramatta Mission when they host the Cowboys at Pirtek Stadium.
Chris Sandow showed signs of his best in a shock Eels win over Penrith last week, but can he inspire another upset against the North Queensland juggernaut?
Eels forward Pauli Pauli and Titans forward Ryan James have both taken early guilty pleas for their respective dangerous contact charges in Round 12.