Melbourne are on course for another finals series and a tilt at the premiership, while the Knights are hoping to avoid the wooden spoon.
Knights halfback Tyrone Roberts has been released from the final year of his contract to take up a two-year deal with Gold Coast, commencing in 2016.
Danny Buderus said his first win as coach was "the most frustrating and enjoyable experience I've ever had" as the Knights climbed off the foot of the ladder.
The Newcastle Knights' bid to avoid the wooden spoon is still alive after clinching a 24-18 win over the Wests Tigers on Saturday.
Both teams are looking towards the future, but both will be hellbent on winning this clash with the threat of the wooden spoon looming large.
Beau Scott may have played his last game for Newcastle after injuring his foot in Sunday's 38-22 loss to the Sydney Roosters.
Interim Knights coach Danny Buderus and Clint Newton hope to put an end to the side's losing habits before the end of the 2015 season.
The Sydney Roosters looked like racking up a cricket score in their eventual 38-22 win over the Newcastle Knights, but a comeback has raised more questions.
A hat-trick from fullback Roger Tuivasa-Sheck has helped the Sydney Roosters survive a Newcastle Knights second half revival.
Roosters players coming off a tense win against premiership heavyweights Canterbury insist they will be up for the task against a struggling Newcastle side.