The equation for these two sides is simple: win at Cbus Super Stadium on Saturday afternoon, and a place in the Telstra Premiership finals series is yours.
It's crunch time in NRL Fantasy and NRL.com's Lone Scout takes a look at all the key ins and outs from all 16 NRL clubs and the form Fantasy players.
While the Sharks and Bulldogs slipped up, the other finals contenders solidified their positions with a couple of weeks remaining before the business end.
The key talking points, injuries and judiciary news from the weekend's NRL Telstra Premiership action.
Penrith players have a simple message for the Titans forwards looking to target 18-year-old whiz-kid Nathan Cleary: he can handle it.
Titans players are promising to turn up the heat on Penrith Panthers wunderkind Nathan Cleary when the teams meet at Cbus Super Stadium on Saturday.
Gold Coast have taken a further step towards a top-eight finish in 2016, handing Newcastle yet another defeat at Hunter Stadium on Saturday afternoon.
After another virtuoso performance from 18-year-old Nathan Cleary, it's clear that whatever Penrith do or don't achieve in 2016, inexperience won't be a factor.
With a possible finals spot on the line for both teams, Penrith found their mojo while the Wests Tigers simply didn't turn up. Here are five talking points.
A dominant opening half has helped Penrith to a big win over Wests Tigers on Friday night to all but secure a top-eight finish in 2016.