Melbourne have celebrated Cameron Smith's 300th game in style, putting in their best performance of the season to embarrass a hapless Panthers.
Penrith fullback Dallin Watene-Zelezniak has been sidelined indefinitely after being hospitalised with a collapsed lung.
Melbourne will be desperate to end their four game losing streak against the side they last defeated, Penrith, in what is also Cameron Smith's 300th game.
Since joining the premiership in 1967, Penrith have made three grand finals and lifted the trophy on two occasions.
Penrith Panthers have announced the signing of young Kiwi playmaker Te Maire Martin on a three-year deal.
Penrith coach Ivan Cleary has lamented the Panthers' poor defence as the key factor in their 20-point loss to the Roosters on Saturday.
They may have defeated the reigning premiers a week ago but the Penrith Panthers had no answers for the Sydney Roosters on Saturday night.
Sparked by a dominant right-edge trio, the Sydney Roosters have claimed their fourth straight win with a commanding victory over the Panthers in Penrith.
Roger Tuivasa-Sheck and Dallin Watene-Zelezniak will meet for the first time as custodians when the Roosters travel to Pepper Stadium on Saturday night.
Penrith are gunning for a season-high three-game winning streak when they host competition heavyweights the Roosters on Saturday night.