The Cowboys are desperate to rediscover winning form ahead of the finals while the Roosters are just keen to end their season on a high.
Roosters forward Kane Evans has entered an early guilty plea to a dangerous contact charge but will escape a suspension this week.
The gap between the NRL's best and the rest shrunk significantly this week, with three of the league's top four teams struggling.
The key talking points, injuries and judiciary news from the weekend's NRL Telstra Premiership action.
Roosters coach Trent Robinson refused to blame Mitchell Pearce's absence for his side's 38-18 loss to the Panthers on Monday night.
A Nathan Cleary masterclass has propelled the Panthers back into the Telstra Premiership top eight with a big win over a Roosters side missing Mitch Pearce.
The Penrith Panthers have moved back into the NRL Telstra Premiership top eight with a commanding victory over the Roosters at Pepper Stadium.
The Penrith Panthers and Sydney Roosters have named their final teams ahead of their Round 22 NRL Telstra Premiership clash at Pepper Stadium.
All the latest team news and expected changes heading into Round 22 of the NRL Telstra Premiership.
If ever there was a time for the Panthers to replicate their 2003 Grand Final heroics, it would be this Monday night against the Roosters.