The Sharks have been advised that five players currently contracted to the club have received 'show cause' notices from ASADA.
The winner here will likely secure a 15th place finish while the loser will probably have the wooden spoon to hold over the off-season.
Cronulla have refused to blame a lack of experience or mounting injury toll for their huge 48-6 loss to an impressive Melbourne on Saturday night.
Melbourne have moved back onto the winners list in emphatic fashion with a 48-6 win over Cronulla in front of 12,185 fans at AAMI Park.
A young Cronulla squad will arrive in Melbourne looking to cause one of the upsets of the season on Saturday night, and the Storm know it.
One team is limping to the line whilst the other is desperately trying to make something of its 2014 campaign.
Skipper Cameron Smith says the Storm need to fix their attitude when taking on teams in the NRL's bottom eight - starting with this week's clash with Cronulla.
After holding the NRL's best attacking team scoreless in the second half on Saturday night, the Sharks were just short on luck at Mt Smart Stadium.
The Warriors have survived a scare from a resilient Cronulla Sharks side to claim a 16-12 victory which keeps their finals plans right on track.
The Sharks must have felt like they were watching a preview of their own worst nightmare when the Warriors demolish the Canberra Raiders 54-18 last Sunday.