The prize for the winner is a showdown with the Storm in Melbourne in a Preliminary Final while the vanquished will be left to rue a good season unfulfilled.
Former NRL coach Matt Elliott takes a look at the four teams involved in the 2015 NRL semi-finals, breaking down their attacking and defensive formations.
Sharks star Valentine Holmes is expected to overcome a quad injury in time for Saturday's NRL semi-final against North Queensland.
An unexpected hiccup for the minor premiers and a scratchy win for Des's Dogs: that is the equation that led us to Friday night's tantalising semi final clash.
Frank Pritchard will be free to face the Roosters in Friday's sudden death semi-final after successfully challenging his dangerous contact charge.
With his side going down to the Sharks twice already in 2015, Cowboys coach Paul Green believes Cronulla should be favourites for their elimination semi-final.
Sharks halfback Jeff Robson is treating every game as if it could be his last in Cronulla colours – but not as if it will be his last in the NRL.
Cronulla captain Paul Gallen will not look past this week's final against the Cowboys as the Sharks continue their quest for a maiden NRL Premiership.
Cronulla hooker Michael Ennis has expressed his relief after escaping suspension for a high shot on Rabbitoh Chris McQueen.
Drawing comparison from how South Sydney defied 43 years of history to win the premiership last season, coach Michael Maguire feels they can go all the way.