The Cowboys sent a warning to the rest of the competition with a a big win over the Titans, securing a top-four finish and leaving Gold Coast's hopes hanging.
North Queensland have leapfrogged Brisbane to finish fourth on the NRL Telstra Premiership ladder with a win over Gold Coast on Saturday night.
The Cowboys and Titans have both confirmed their final 17 ahead of their Round 26 NRL Telstra Premiership clash at 1300SMILES Stadium on Saturday night.
With a top four spot on offer for North Queensland and a guaranteed place in the finals the carrot for the Gold Coast, everything is on the line.
With Jarryd Hayne soaring back into the NRL and reassuming his place as a top-class fullback, and old rivalry with Johnathan Thurston is set to reignite.
A remorseful Ryan James has spoken out about the tackles that have ended the seasons of James Tedesco and Reagan Campbell-Gillard in recent weeks.
Titans winger David Mead has conceded that after 145 games in the top grade he may have played his final game for the club.
The Cowboys are back in form and back at home against a Titans outfit who must win to guarantee a return to the finals for the first time since 2010.
In each of their past six home losses, the Cowboys have conceded 18 points or less. Can the Titans' defence hold out the resurgent North Queensland side?
Titans coach Neil Henry believes his former Cowboys side have the necessary depth to cover for injured co-captain Matt Scott.