Can an injury plagued Panthers outfit overcome a resurgent Gold Coast? History says whatever the outcome, it will be a high scoring affair.
Can the Cowboys continue their blistering form or will the enigmatic Warriors steal the show in Townsville?
There will be State of Origin and International stars a-plenty when these two teams take to AAMI Park on Saturday night.
The latest injury news, moves in betting markets and where the coaches think the game will be won and lost.
Panthers centre Robert Jennings could be the most exciting rookie of 2015 given the appraisal of Penrith coach Ivan Cleary ahead of his NRL debut.
When Johnathan Thurston laces them up for the 250th time in the NRL on Saturday night he will surpass the one most consider the greatest of them all.
Off the back of his memorable match-winning try, Dragons prop Mike Cooper said the recent birth of his son has proven to be a life-changer.
Rep round can't come soon enough for Wayne Bennett, as his side's injury toll grows following their Round 7 loss to the Dragons.
Manly players and coach Geoff Toovey, as well as the man at the centre of the speculation, have all refused to elaborate on DCE's likely destination in 2016.
The injury-ravaged Sea Eagles simply can't cop a break, with further injuries to stars Jamie Lyon and Kieran Foran causing even more headaches for Geoff Toovey.