Both sides are desperate for victory and are playing at almost full strength for this Friday night showdown.
Queensland Maroons forward Aidan Guerra and NSW Blues opponent Ryan Hoffman are ready to Kick Bowel Cancer by taking a simple 60-second online test.
The calvary has arrived for the Knights and Dragons, Cooper Cronk will back up for the Storm, while Brisbane should be close to full-strength in Round 18.
The latest injury news and estimated return dates heading into Round 18 of the 2015 NRL Telstra Premiership season.
Cowboys football manager Peter Parr has revealed his desire to keep 23-year-old sensation and Townsville junior Michael Morgan a one-club player.
It's yet to be confirmed whether he'll play in Origin III, but according to Blues skipper Paul Gallen, Michael Ennis has already disrupted the Maroons.
Well aware of the demands of an Origin series, Roosters playmaker James Maloney is aiming to ease the pressure off his halves partner in Round 18.
He's set to match Darren Lockyer's record for most State of Origin appearances and his fellow Queenslanders say Cameron Smith was made for Origin football.
Titans rookie Karl Lawton is using the life of Arnold Schwarzenegger as the blueprint to bring his rugby league dreams to fruition.
Returning Maroons halfback lives for the opportunity to test himself in pressure situations. Wednesday night's Origin decider will give him such a chance.