The Rabbitohs travel north to face a Cowboys side that welcome back two of their best in Jason Taumalolo and Lachlan Coote on Friday night.
Two of the best performers from Round 4 renew hostilities in Sydney's battle of the beaches.
The Broncos face their first trip to ANZ Stadium in 2017, travelling to face the Canterbury Bulldogs in a match-up with big implications for both sides.
The players to watch and predicted results from Round 5 of the National Youth Competition.
Matt Scott is still helping to guide the Cowboys forward pack towards a second premiership, despite suffering a season-ending knee injury.
Rabbitohs centre Sifa Talakai says he fully supports his coach's decision to drop him after a below-par effort in Round 1.
The Warriors continue to frustrate fans and have a tough season coming up, who is the quickest player in the NRL and should teams take the two?
There may be pressure mounting on Bulldogs coach Des Hasler but milestone man Aiden Tolman says the onus is on the player to turn things around.
Manly back-rower Curtis Sironen says Saturday's huge 36-0 win over Canterbury was his best performance so far in the maroon and white.
Gold Coast Titans forward Ryan James is free to play against the Warriors this weekend after being found not guilty of a shoulder charge at the NRL judiciary.