After a strong start to the season, injuries played their part in disrupting the Rabbitohs' year. Back on track, the premiers face a tough run to the finals.
The Sharks have bounced back into form in recent times after a sluggish start to the season, but will it be enough to carry them into finals football?
Injuries and suspensions threatened to derail the Dogs' season but with almost a full squad available the 2014 grand finalists are set for another big finish.
Daly Cherry-Evans was injured as the Cowboys continued their push towards the finals with a solid win over the Sea Eagles at Brookvale Oval on Monday night.
The Broncos have extended their lead at the top of the Telstra Premiership ladder with a big win over Wests Tigers at Suncorp Stadium on Sunday afternoon.
The Sydney Roosters have flexed their premiership muscle, keeping the Warriors to nil in a big win at Allianz Stadium on Sunday afternoon.
St George Illawarra have slumped to a sixth consecutive loss against an injury-hit Rabbitohs side, who scored two late tries to claim victory at the SCG.
Off the boot of star five-eighth Jarrod Mullen, the Newcastle Knights have emerged victorious 30-2 over the Gold Coast Titans to end a six-game losing streak.
Melbourne have celebrated Cameron Smith's 300th game in style, putting in their best performance of the season to embarrass a hapless Panthers.
A knee injury to Eels fullback Corey Norman has added injury to insult after Parramatta were outplayed and outmuscled by the Bulldogs.