There will be no shortage of desperation on Sunday afternoon at Allianz Stadium as both sides desperately try to keep their finals hopes alive.
The Rabbitohs and the Titans are locked together on 12 points apiece sitting just outside of the top 8 at the halfway point of the NRL season.
Newcastle's youth policy is starting to show signs of paying off but the Knights will be up against it against the defending premiers.
Round 13 marks a pivotal point in the season for the Warriors, while for the Broncos it's about trying to fight their way out of an unfamiliar position.
The Melbourne Storm will be out to make it six wins in a row when they take on the Panthers on Saturday night, but they may be missing their biggest stars.
The Sea Eagles can expect a frosty reception when they arrive in Canberra for this all-important clash to kick-start Round 13 of the NRL Telstra Premiership.
The Eels lost skipper Kieran Foran late in the first half to a shoulder injury but have held on to a tight 20-18 win over the Newcastle Knights.
A three-try burst in the space of 11 minutes has propelled the Canberra Raiders to a crucial 32-20 win over the Bulldogs at GIO Stadium on Sunday afternoon.
Missing Josh Dugan, the Dragons have clinched a crucial four-point victory over the Cowboys without several of their Origin stars to jump into the top eight.
The Wests Tigers have held off a fast finishing Broncos at Suncorp Stadium to claim an important and dramatic one point victory.