Friday night's clash with the reigning premiers looms as a huge challenge for the underperforming Tigers, who are again without their two key players.
North Queensland second-row forward Gavin Cooper scored a hat-trick of tries in six second-half minutes as the Cowboys overran Parramatta at Pirtek Stadium.
Moses Mbye was moved to five-eighth and played a big role in Canterbury's big win over St George Illawarra as the Bulldogs ran away with the game late.
The Cronulla Sharks have scored their second win over the Roosters in 2015, downing the Tricolours in a low-scoring affair at Remondis Stadium on Sunday.
The Storm never really needed to get out of second gear in disposing of an error-prone Penrith outfit at Pepper Stadium on Saturday night.
Reigning premiers South Sydney have made it three consecutive wins with a dominant victory over the New Zealand Warriors in Perth.
Raiders halves Blake Austin and Sam Williams were the standouts as Canberra outclassed the Knights in Newcastle on Saturday.
The Broncos stampeded back to the top of NRL Telstra Premiership table after trampling Manly at Suncorp Stadium.
The Gold Coast Titans managed to withstand a second-half surge from the Wests Tigers without halfback Kane Elgey in a gutsy win away from home.
Chris Sandow showed signs of his best in a shock Eels win over Penrith last week, but can he inspire another upset against the North Queensland juggernaut?