The Wests Tigers host the Newcastle Knights with both teams desperate to bounce back from some big losses last start.
You know it's a special kind of rivalry when the game dwarfs an individual milestone as great as Johnathan Thurston's 250th for North Queensland.
The NRL Telstra Premiership will break new ground this Saturday, hosting a game in New Plymouth for the first time when the Warriors take on the Raiders.
It doesn't seem all that long ago the Dragons upset the Rabbitohs in a low-scoring slugfest on a soggy SCG pitch back in Round 3.
A strong second half has seen the Titans record an impressive victory over the Roosters at Cbus Super Stadium on Monday night.
The hot and cold Bulldogs were at their scorching best on Sunday afternoon as they bullied their way past an injury-ravaged Wests Tigers side at ANZ Stadium.
Sharks wingers Valentine Holmes and Sosaia Feki have produced a seven-try haul in Cronulla's record win over Newcastle Knights at Hunter Stadium.
A strong showing from Broncos fullback Darius Boyd and five-eighth Anthony Milford has inspired Brisbane to a big 'away' win over Manly at Suncorp Stadium.
Melbourne have claimed one of the most memorable victories in the club's history, getting the better of the 2015 premiers at Suncorp Stadium on Saturday night.
Trailing 18-14 at the break, the Panthers have scored 16 unanswered points in the second half to overcome a spirited Warriors side at AMI Stadium.