Penrith are headed back to the finals and a win over a depleted Manly side could move Anthony Griffin's men to as high as sixth on the ladder.
The Cowboys are back in form and back at home against a Titans outfit who must win to guarantee a return to the finals for the first time since 2010.
The Newcastle Knights are on track to finish the season with the worst record since the Gold Coast Seagulls' year from hell in 1993.
The Bulldogs are finals-bound but have lost their last two while they face a Rabbitohs team chasing a fourth straight victory.
The Broncos will be hoping to send Corey Parker out a winner and secure a home final in the process against a Roosters side that has found form of recent weeks.
A stunning hat-trick from prolific young fullback Bevan French has seen the Eels sign off both Monday night football and their home ground in style.
The South Sydney Rabbitohs have ruined the Knights' Old Boys Day celebrations for the second time in five years following their win on Sunday afternoon.
Late tries to Mitch Moses and Kevin Naiqama have snatched a crucial two competition points for the Wests Tigers against the Warriors at Mt Smart Stadium.
A big second half has seen the Sharks end their four-game winless run, defeating the Roosters at Southern Cross Group Stadium on Saturday night.
A field goal from Panthers captain Matt Moylan with barely minutes remaining has confirmed Penrith's spot in the top eight following their win over Gold Coast.