A second-half surge has seen the injury-riddled Bulldogs run over the top of the Knights 22-12 in a gripping Friday evening clash in Newcastle.
The Broncos have posted an impressive victory over the Roosters, but halfback Ben Hunt failed to finish the contest, leaving the field with a hamstring injury.
It's a grand final rematch with the in-form Storm taking on a Sharks side that is still warming up in 2017. Can Melbourne take their revenge?
The Eels are looking to snap a three-game losing streak but face a rejuvenated Warriors side boasting an all-star spine.
Konrad Hurrell returns for a Titans side in the midst of one of their worst ever runs with injury as the Raiders travel to Cbus Super Stadium on Saturday night.
Wests Tigers will play for the first time under new coach Ivan Cleary in one of the NRL's toughest road trips: a clash with the Cowboys at 1300SMILES Stadium.
Two of the form teams collide at Lottoland on Saturday afternoon, with the Sea Eagles and Dragons to test themselves after an impressive start to 2017.
The Panthers and Rabbitohs are both desperate to return to the winners' circle and this contest shapes as an intriguing battle.
Both these teams bounced back from horror Round 4 results with brave performances last week and will be keen to back it up with a winning effort here.
Two premiership contenders coming off losses meet on Thursday night when the Brisbane Broncos host the Sydney Roosters at Suncorp Stadium.