Bryce Cartwright has led the Panthers to a big victory over South Sydney at Pepper Stadium in Round 17.
One team is trying to bounce off the bottom of the NRL Telstra Premiership ladder, while the other is looking to break into the top eight.
Winless through the month of June, the Dragons desperately need to breathe some fire back into their campaign before their chances of a top four start slipping.
These two desperate western Sydney teams are both outside the eight and at risk of losing touch with the finals contenders.
With both teams securing essential wins last weekend, this game could prove to be a make or break one in the grand scheme of things.
The NRL has released the fixtures for the final six rounds of the 2015 NRL Telstra Premiership season, with a number of blockbuster clashes in the run home.
A three-try blitz in the opening 15 minutes has helped the Bulldogs to a comfortable win over the Melbourne Storm at a sold-out Belmore Sports Ground.
The Panthers have thoroughly outclassed Wests Tigers with a big victory in front of a passionate but frustrated crowd at Leichhardt Oval on Sunday afternoon.
The Sydney Roosters have fought their way to a tough victory over the Gold Coast Titans at Central Coast Stadium on Sunday afternoon.
The Eels have repaid the faith of long-suffering fans after a rough week off the field, holding out a fast-finishing Dragons side in a tense win.