Despite losing James Maloney and Luke Lewis through injury, the Sharks have rallied to get the better of the Titans at Southern Cross Group Stadium on Sunday.
A field goal to Lachlan Coote and a late Kyle Feldt try has seen the Cowboys claim their first win on the road for 2016 over the Panthers at Pepper Stadium.
Manly have claimed their third win of the season, getting the better of the Warriors at Mt Smart Stadium on Saturday night.
A first-half blitz helped the Parramatta Eels to an emphatic 36-6 win over Canberra at Pirtek Stadium on Saturday.
The Roosters have recorded their first win of the season with a dominant victory over South Sydney at ANZ Stadium on Friday night.
The Brisbane Broncos have prevailed 26-0 over the Dragons in a scrappy contest at Suncorp Stadium on Thursday.
Melbourne will look to extend their unbeaten home start to the 2016 NRL Telstra Premiership season to four matches when Canterbury comes to town.
For the second season in succession the Titans are handing a half an NRL debut at the home ground of the Sharks , but can Cameron Cullen make the difference.
Both teams head into this tantalising Round 6 fixture on the back of wins; albeit in very contrasting circumstances. Expect another nail biter on Saturday.
Newcastle have beaten the Tigers in four of their past five meetings, but can they get their first win of the season when James Tedesco comes to town?