Aidan Sezer goes up against his former club, with the Titans having already enjoyed one surprise win over the Green Machine this season.
An out-of-sorts Manly side travel north to face the premiers on their own turf, but Cowboys coach Paul Green will be without one of his key men.
A Cooper Cronk field goal in the 85th minute saw the Storm snatch a 19-18 golden point victory over the Tigers the last time these teams met back in Round 7.
Early-season hotshots the Broncos lost three straight before last weekend's rest while Des Hasler's men had just one win in their three prior games.
Fresh off the bye, the Sharks will be searching for their 11th consecutive victory over a Warriors side who head across the Tasman on a three-game winning run.
Newcastle get some much needed troops back, but will it be enough to upset the Dragons on Saturday afternoon?
Andrew Voss predicts the Maroons will win Game Two and looks at Manly's woes, Radradra, the Titans' form and the importance of a huge Round 16.
Fresh off a bye and a last-start win over Manly, Penrith return home to face a South Sydney side desperate to win for the first time since Round 11.
The Titans continued their impressive 2016 season with a controlled performance against Manly, earning a comfortable 30-10 win at Cbus Super Stadium.
Despite a late surge from the Roosters, the Warriors have held firm to clinch a crucial victory in a low-scoring affair at Mt Smart Stadium on Sunday night.