The Sharks' unbeaten run is over but they're expected to bounce back against a Dragons side that welcomes back star fullback Josh Dugan this week.
These sides last met in the season-opener at Pirtek Stadium, and have both faced their separate challenges ahead of their meeting on Friday night in Brisbane.
It's last drinks at the last chance saloon for Manly's finals hopes while the Bulldogs will be looking to cement their place in the all important top four.
The Penrith Panthers have moved back into the NRL Telstra Premiership top eight with a commanding victory over the Roosters at Pepper Stadium.
A spirited 80 minutes from the Wests Tigers has earned them a top-eighth berth after downing North Queensland at Leichhardt Oval on Sunday afternoon.
Two length of the field intercept tries has led the Warriors to a crucial victory over the Titans at a packed Gold Coast on Sunday afternoon.
South Sydney pushed them all the way but Melbourne escaped with a 15-14 golden point win over the Rabbitohs in a thriller at AAMI Park on Saturday night.
Star hooker Josh Hodgson has inspired the Canberra Raiders to a 30-14 win over the league-leading Sharks in Cronulla on Saturday night.
A crucial charge down from Sam Kasiano swung the game Canterbury's way as the Bulldogs ran out 28-14 winners over the Knights in Newcastle on Saturday.
A resilient Parramatta Eels have stolen a 10-9 win that all but ends Manly's finals hopes in a low-scoring thriller at Pirtek Stadium on Friday night.