The Warriors have a strong home record against the Cowboys but will be up against it in a match against one of this season's genuine premiership threats.
A must-win clash for both of these title contenders as South Sydney look to shore up a likely top-four finish and Canterbury try to guarantee a finals berth.
Still bruised by last week's heavy defeat against Brisbane, the Dragons will have to defy their recent history against Penrith if they are to prevail here.
Melbourne have scored 30 unanswered points to down fellow top eight rivals the Sharks at Remondis Stadium on Monday night.
The Bulldogs have prevailed over the Titans at Central Coast Stadium on Sunday afternoon, with the match featuring some of the tries of the season.
The Sea Eagles have downed the Raiders in incredible circumstances, coming back to continue their late-season charge to the top eight on Sunday afternoon.
They didn't lead until the final 10 minutes but the Roosters have escaped with a 28-18 victory over a determined Parramatta Eels outfit on Saturday night.
The Penrith Panthers have snapped up a five-game losing streak, whilst also handing the New Zealand Warriors their fifth-straight loss, with a 24-10 win.
The Newcastle Knights' bid to avoid the wooden spoon is still alive after clinching a 24-18 win over the Wests Tigers on Saturday.
The Ben Hunt and Anthony Milford show returned to Suncorp Stadium after a brief hiatus as the Broncos brushed aside the Dragons with ease.