A lot has changed for these teams since the Rabbitohs beat the Roosters in Round 2, with one side on track for top spot and the other just hanging on.
The finals have come a week early with a grudge match between two premiership heavyweights to begin Round 26, with history very much with the visitors.
All the key NRL Fantasy news from the official team lists ahead of the final round of the 2015 NRL Telstra Premiership regular season.
He turned down an NRL chance two years ago, Raymond Talimalie could get a second chance after being named the best player in the Auckland club competition.
Following the loss of influential prop Jared Waerea-Hargreaves, Roosters back-rower Boyd Cordner has stepped up to become one of his side's best.
If Cronulla fullback Michael Gordon got his way back in May, he would be playing his final game of the season this weekend against the Raiders in Eels colours.
The Rabbitohs aren't going to dwell on their heavy loss to Brisbane, instead choosing to focus their attention on their clash with rivals the Roosters.
Nate Myles will be forced to sit out his side's season-ending trip to Townsville with a thumb injury, in what would've been his final game in Titans colours.
After leaving the field with a neck injury in Round 24, James Tamou has been named to return for the Cowboys' clash with the Titans on Saturday night.
It's a cruel irony that after one of his best performances at five-eighth Daniel Mortimer has to come to grips with the fact that his future lies elsewhere.