It's time to get your footy tips in, so check out NRL.com's full match previews for all eight of this week's games, starting with Thursday night's blockbuster between Souths and Brisbane.
The Rabbitohs are eyeing a first minor premiership in 25 years and the Broncos cling to hopes of a finals appearance... this game has everything going for it.
These teams' fortunes have fluctuated wildly recently – now this clash could even determine who fills the final spot in this year's top eight.
The Dragons head to Canberra looking for their first win in the national capital since – wait for it – 2000!
One team is limping to the line whilst the other is desperately trying to make something of its 2014 campaign.
There's plenty to play for in this Foundation Cup clash, with the Tigers looking to restore pride and the Roosters hoping to maintain momentum.
The Knights will be looking to disrupt the Warriors' finals charge but the visitors are boosted by the return of their star halfback.
Manly travel north hoping to maintain their spot at the top of the NRL perch against what will undoubtedly be a spirited Titans side under new coach Neil Henry.
Two top-five teams go at it in a clash that could have a huge impact over the final make-up of the top four.