It's recognised as the third official State of Origin match but is built on more than two decades of women's interstate rivalry.
Queensland have not beaten NSW in four years - five if you include a 4-4 draw in 2015.
Prior to that, the Maroons held a 17-year stranglehold on the bragging rights.
Are they about to reclaim their status with a win on the Sunshine Coast?
The match has officially been declared a sellout with all tickets snapped up by Thursday afternoon.
NRL.com has asked two stalwarts from their respective states to outline the case for why their team will be victorious at Sunshine Coast Stadium in the Harvey Norman women's Origin on Friday night.
Will NSW retain the women's Origin shield?
For - NRL.com expert and ex-NSW captain Tarsha Gale
There are a few reasons why I think NSW can make it three wins in a row under the State of Origin banner.
The first is Andy Patmore hasn't mucked around, making hard decisions and picking on form, so we know the team going out there will be full of confidence and belief.
Match: QLD Maroons v NSW Women
Round 1 -
Venue: Sunshine Coast Stadium, Sunshine Coast
For those who may question a couple of players who didn't have the best of NRLW campaigns, I also have no doubts they'll rise to the occasion having experienced Origin success before.
The talk is the biggest advantage for the Maroons is they've kept a lot of Broncos players so they've got the continuity and are playing on home turf.
Let's not forget eight of those players are on Origin debut and that's no easy feat to overcome mentally with self and external pressure.
Qld Maroons v NSW Women
The way it's being spoken about, it's the Maroons' best chance to win an Origin match on home turf in years and that will only raise the heart rate levels for even their most experienced players.
Being in camp for two weeks can also only be an advantage for Patmore's outfit as well with their own squad changes.
Patmore has had Corban McGregor and Melanie Howard working together for a fortnight in camp and that is an added bonus for the halves.
McGregor has shown she's a real thinker and Howard has a great kicking game.
They've got to put Tamika Upton under some pressure by kicking to the corners and make her do a lot of work.
Upton likes to come into the game particularly late when the middle opens up.
It's the same with Ali Brigginshaw, whenever you give her too much time, she strikes. I think the Blues have worked that out in recent years and know how to put pressure on her.
Savannah surprises Sergis
Hannah Southwell and Millie Boyle will control that middle with their defence and will go after Brigginshaw and limit her creativity.
I honestly can't see a weak point in the NSW team that Queensland can target, whereas in the centres for the Maroons I see some vulnerability.
Lauren Brown and Julia Robinson are on debut. It shouldn't be underestimated how hard it is to defend in the centres so I think the Blues can crack them there.
We've got a formidable and experienced centre pairing in Isabelle Kelly and Tiana Penitani, while Jessica Sergis can come in off the wing and get more involved in the game.
They're all dangerous when they've got the ball in their hands and McGregor and Howard will create the gaps for the outside backs.
A lot has been made about Kelly but she'll be desperate to prove why she is considered one of the best centres in the world.
She will be frustrated with how her year has panned out but is a proven performer at this level and will be looking to finish the year in style.
NSW have proven to come home strong and not even the Sunshine Coast crowd or humidity should halt their chances this year.
Boyle back in blue and ready to hoist another trophy
Against - Channel Nine commentator and ex-Queensland forward Jo Barrett
The Maroons will win this year because they're better balanced, have got the home-ground advantage and the pain of losing in the past will spur them on in front of family and friends.
State of Origin is a different beast in Queensland and the girls will finally have a lot of supporters who haven't been able to get around them over the last couple of years.
You can't underestimate what local support does for a team.
There are a lot of players in that line-up who have lost to NSW in the past and you learn so much from a loss, it's really in the back of their minds.
Hearing the NSW chant at North Sydney Oval in previous years has haunted them in some ways.
Hearing the Queensland chant will provide them with a significant boost.
2020 Veronica White Medallist – Georgia Hale
When I look at the line-up and individual match-ups I think we've got the incredible experience and a balance in the team we haven't had for years.
You've got Steph Hancock in her 16th year and Ali Brigginshaw in her 10th year, while Karina Brown and Rona Peters have had huge experiences under pressure and I think that's a huge advantage too.
The fact that 10 Broncos are in the named 17 also offers a lot of settled combinations straight away.
We've got a spine that is Jillaroos quality and would probably walk into the Australian line-up if a team was announced tomorrow.
If you've got the class of Brigginshaw and can put her at lock because you've got Tarryn Aiken and Zahara Temara there, you're doing pretty well.
That's three quality ball-players on a field. Sometimes you're lucky to have one or two of those and Queensland have three this year on the paddock which will offer more in attack.
Fastest and Best - Part II
And where do you start with Tamika Upton? She is the X-Factor and you put her in with those girls in the spine and they're going to hard to contain.
They whole lot of them are fast and it's something Queensland finally have, some speed back in the side that has been missing for a few years and somewhere NSW have had the edge in recently.
A couple of debutantes in Shenae Csiesolka and Lauren Brown are great additions and add pace out wide to match Jessica Sergis and Isabelle Kelly.
Someone like Julia Robinson, who has been around a while but hasn't had an opportunity due to injuries will also slot straight in with ease.
I can't see it going any other way this year for the Maroons. It's their time to bring the shield home.
The views in this article do not necessarily express the opinions of the NRL, ARL Commission, NRL clubs or state associations.