Cam Smith shows off his teal-coloured nails to raise awareness for Ovarian Cancer Australia.

Melbourne are bracing for a Saturday night blockbuster with a feminine touch as they get set to welcome the reigning premiers to AAMI Park.

The Storm currently sit in second place on the NRL ladder and a win on the weekend would entrench the side inside the top eight ahead of what is always a tricky origin period.

The Rabbitohs are one win outside the top four having broken their three game losing streak against the Dragons on Monday night.

However the visitors have been dealt a blow with halfback Adam Reynolds ruled out for at least the next month with a hand injury.

The importance of Saturday night's game is not lost on the Melbourne captain.

"We've had a couple of home games this year, but these guys are the reigning premiers and they had a strong win [on Monday] night against the Dragons," Smith said.

"We've got a pretty healthy rivalry with the Rabbitohs given there's a few connections with the Storm in the past there. We know that we are coming into a pretty hectic schedule for us with Origin so we need to play well to be a chance of winning."

Melbourne piled on three unanswered tries on Sunday in a second half romp against the Eels for their sixth win of the year.

"I think we simplified things a lot more on the weekend, more so in the second half," Smith said.

"I think we've just got to put the fancy football away at times and just play some footy that builds pressure on the opposition rather than ourselves."

As he fronted the media on Tuesday there was something noticeably different about the Kangaroos, Maroons and Storm skipper – his nail polish.

Smith was showcasing his teal-coloured hands in order to raise awareness for Ovarian Cancer Australia.

"The nails are the colour of Ovarian Cancer Australia which I am an ambassador for. It is just about building awareness about the disease that affects a lot of women in Australia and throughout the world every year," Smith said.

"Obviously me being a male and wearing nail polish it is just a reminder that it is not only the women in our lives that are affected by the disease it is the brothers, husbands and fathers that are affected by it as well."

The charity will also receive a boost when it is presented with a $20,000 cheque from the Crown Resorts Foundation, who will also donate an additional $1,000 for every try that is scored on Saturday night. 

For the third successive year Melbourne will also wear their pink and purple jersey in support of Women in League round.

The Storm and Rabbitohs will kick off at 7.30pm on Saturday night at AAMI Park.