Eels bench hooker Isaac De Gois is set for a long stint on the sidelines while Warriors hooker Thomas Leuluai's season could be over after both were injured in the Round 10 clash between the Eels and Warriors at Pirtek Stadium.

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Leuluai stepped off his right leg and dropped to the ground with no-one on him and had to be assisted from the field in the 24th minute, while De Gois was injured in a tackle in the 48th and immediately signalled to the sideline that he needed to come off.

After the game neither coach was able to confirm the nature of the injuries both neither were optimistic.

"It's a knee injury. Again, I think it's the worst one. It might be ACL, but we'll have to get it confirmed. It's one of those innocuous ones and they usually turn out to be the worst case," Warriors coach Andrew McFadden said of Leuluai.

However he said Origin hopeful Ryan Hoffman, who was taken off with concussion in just the third minute, would be fine to play after the Warriors' Round 11 bye – indicating that in the likely event Hoffman is selected for NSW he should be OK to play in the May 27 series opener.

Asked if De Gois had fractured his cheekbone, Eels coach Brad Arthur said, "Yeah I think so."

"He's up at hospital now. He's in a fair bit of pain."

If scans confirm the fracture De Gois would miss at least a month of football.