Panthers captain Matt Moylan in action against Souths in Round 16.

The Wests Tigers and Penrith Panthers have finalised their line-ups for Saturday night's clash at ANZ Stadium.

New recruit Zak Hardaker will make his Panthers debut off the bench, while Sam McKendry and James Fisher-Harris join the starting pack and Leilani Latu drops back to the interchange, with Suaia Matagi and Sitaleki Akauola dropping out of the side.

The Tigers are 1-17 as named on Tuesday.

Wests Tigers 
1 James Tedesco
2 David Nofoaluma
3 Tim Simona
4 Kevin Naiqama
5 Jordan Rankin
6 Mitchell Moses
7 Luke Brooks
8 Aaron Woods
9 Dene Halatau
10 Sauaso Sue
11 Josh Aloiai
12 Chris Lawrence
13 Elijah Taylor
Interchange:  
14 Tim Grant
15 Ava Seumanufagai
16 Robbie Farah
17 Kyle Lovett

Panthers 
1 Matt Moylan
2 Josh Mansour
3 Waqa Blake
4 Tyrone Peachey
5 Dallin Watene Zelezniak
6 Bryce Cartwright
7 Nathan Cleary
20 Sam McKendry
9 Peter Wallace
10 Reagan Campbell-Gillard
11 Isaah Yeo
12 Trent Merrin
17 James Fisher-Harris
Interchange:  
8 Leilani Latu 
15 Jeremy Latimore
16 Chris Grevsmuhl
19 Zak Hardaker