Scans have revealed that Rabbitohs captain Greg Inglis has injured the anterior cruciate ligament in his left knee which could see him sidelined for six months.
Inglis's injury occurred in the opening minutes of Friday night's match against the Tigers however it was not diagnosed as an ACL injury until the scans were taken this morning.
Rabbitohs General Manager of Football Shane Richardson, said: "The injury occurred in the first instance in the match, not as a consequence of Greg playing on further.
"Our medical staff further examined the injury at the half-time break and they felt the knee was stable, and they along with the head coach and Greg himself agreed that he would go on and play in the second half.
"I, along with the rest of our club, have the greatest of confidence in our medical and coaching staff to make the best possible decisions about our players' wellbeing.
"We have the quality of squad to continue our quest throughout the season and Greg, as our captain and senior leader, will continue to play a significant role throughout the year."