There were upsets last weekend and if history is any guide, there will probably be a few unexpected results this round too.
St George Illawarra broke their duck for the season last Sunday when they surprised Cronulla in their local derby while the Warriors showed they have banded together nicely in Gosford by accounting for North Queensland.
It's time to get your tips in - enter them now to make sure you don't miss out.
If you need help on how each team is travelling, Jamie Soward's Power Rankings is the best place to go for an accurate gauge on who's travelling well and who's doing not so well.
Here are the NRL.com expert panel's predictions for the round.
Fox Sports reporter Hannah Hollis has reclaimed the outright lead after tipping seven winners last round but is only just ahead of six-way tie with former NRL coach Matthew Elliott, Sharks premiership winner Michael Ennis, retired Jillaroos prop Ruan Sims and the mysterious NRL Fantasy guru Loan Scout in the race to be this year's top tipster.
According to our panel, there is only one match with a unanimous favourite with everyone predicting the Rabbitohs to get the better of the Warriors on Saturday.