City Origin coach Brad Fittler has been forced into making two more changes for this weekend's City-Country clash in Dubbo, with second-rower Wade Graham and halfback Trent Hodkinson ruled out through injury on Wednesday night. 

Graham will be replaced by Parramatta forward Darcy Lussick, while 18th man Michael Lichaa takes Hodkinson's spot on the bench. 

Former NSW representative Jamie Buhrer will start at lock and Penrith back-rower Tyrone Peachey comes into camp as the new 18th man. 

It is the second and third changes Fittler has had to make this week, after five-eighth Aidan Sezer was ruled out with an ankle injury on Monday. 

The new City Origin line-up: 
Fullback: Matt Moylan (Penrith Panthers)
Wing: Daniel Tupou (Sydney Roosters)
Centre: Will Hopoate (Parramatta Eels)
Centre: Dylan Walker (South Sydney Rabbitohs)
Wing: Jorge Taufua (Manly Sea Eagles)
Five-eighth: Josh Reynolds (Canterbury-Bankstown Bulldogs)
Halfback: Adam Reynolds (South Sydney Rabbitohs)
Prop: Andrew Fifita (Cronulla Sharks)
Hooker: Beau Falloon (Gold Coast Titans)
Prop: Aaron Woods (Wests Tigers)
Second-rower: Tony Williams (Canterbury-Bankstown Bulldogs)
Second-rower: Ryan Hoffman (c) (Melbourne Storm)
Lock: Jamie Buhrer (Manly Sea Eagles)

Interchange: Darcy Lussick (Parramatta Eels), Michael Lichaa (Cronulla Sharks), David Klemmer (Canterbury-Bankstown Bulldogs), Tim Grant (Penrith Panthers).

18th man: Tyrone Peachey (Penrith Panthers)

Coach: Brad Fittler