South Sydney centre Dylan Walker and winger Aaron Gray have been discharged from St Vincent's hospital, having recovered from an overdose of prescription painkillers.
The pair was rushed to hospital in the early hours of Tuesday morning and both spent time in intensive care.
"Firstly I'd just like to thank the staff, the ambulance officers and the nurses at St Vincent's who have been looking after us for the past few days," Gray said.
"We really appreciate it, and could not have asked for better care.
"Secondly, we'd like to apologise to all our family and friends for what we put you through over the past few days. We know it hasn't been easy.
"Thirdly, we'd like to say that we have learnt from our mistakes and we hope everyone can learn from this, not only rugby league players but people in general, to just take prescription medication as it is on the prescription box."
Walker echoed Gray's words.
"I can't thank enough the doctors, nurses and ambulance people at St Vincent's Hospital," Walker said.
"It's a mistake we have made and a lesson we have learnt. We hope everyone can take a lesson out of this."
Rabbitohs chief executive John Lee said toxicology reports confirmed that illicit drugs were not taken by Walker or Gray.
"This has been a very difficult time for our club," Lee said.
"In terms of personal responsibility, we realise some of our players have made mistakes and that is important that recognition is made.
"We will take the responsibility to put in better protocals and to make the right changes and to have the right levels of education to prevent this from occurring again.
"I currently sit on the Australian Sports Commission, and it's fair to say prescription medications are not a rugby league issue only. They are an issue across all competitive sport and it's something that we need to face fair and square."
Lee also said the South Sydney club would volunteer to be at the forefront of a new trial of testing for prescribed medicines through the use of hair follicles.
"It's not an overnight fix, it starts with real conversations," Lee said.
Both players had post season surgery last week, Walker on his hand and Gray on his knee, and were prescribed painkillers post-operation.