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Eels centre Michael Jennings.

The NRL has suspended Michael Jennings after the Eels centre tested positive to banned substances, the league announced on Saturday.

Jennings has been provisionally suspended after returning a positive A-sample for Ligandrol and Ibutamoren and now has the opportunity to have his B-sample analysed.

He was tested on September 21 with the result received by Sport Integrity Australia on October 9.

Jennings had been set to play in Saturday night's elimination final against South Sydney.

"Michael Jennings has been stood down from today's game and ongoing training/playing responsibilities while the process runs its course, which under the policy includes the opportunity to have his B-sample analysed," the Eels said in a statement.

"The club has been in contact with Michael and will continue to offer him and his family our full wellbeing support."

The 32-year-old former NSW Origin centre and Tonga international signed a new contract with the Eels in July, keeping him at the club for the 2021 season with an option in his favour for 2022.

Brad Takairangi and Haze Dunster are set to start in the Eels backline against the Rabbitohs, with winger Blake Ferguson also ruled out due to a knee injury.