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Manly's horror 46-6 loss at home to Penrith on Thursday night was compounded by yet another potentially long-term injury in the club's cursed back row position, with Morgan Boyle the latest to be struck down.

Already minus Curtis Sironen (knee) and up-and-comer Haumole Olakau'atu (elbow) plus late-blooming former Eel Andrew Davey with a season-ending ACL injury, the club started Thursday night with prop Boyle and five-eighth Josh Schuster on the edges before Boyle's shoulder popped out in a tackle in the second half.

"Dislocated shoulder so that doesn't look good," coach Des Hasler said of Boyle. "It's not good news for Morgan so we'll wait and see."

Centre Moses Suli also hobbled off after a knee in the back but Hasler hoped he would recover in time to face the Warriors next Friday.

"Moses Suli's hurt his back. It will help that there's a long turnaround," he added.

Fullback Dylan Walker also limped off in the final minutes but Hasler described that change as precautionary.

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The coach suggested the imminent return of some reinforcements will help, but while star fullback Tom Trbojevic (hamstring) is a chance next week and winger Jorge Taufua (Achilles) is also close, neither will be the magic bullet to fix what is going awry with the club's ball, handling and edge defence.

"We're exploring that (Trbojevic returning next week) but that's not going to fix it," Hasler said.

"It's not going to make us hang on to the ball, and it's not a decision we're going to rush. There was certainly a bit of miscommunication and disconnect, we need to address that."

Olakau'atu and Sironen are still two and four weeks away respectively, he added.

"You always go through tough periods. This is another one. These experiences are going to be part of our recovery."

Of the game itself, in which the Sea Eagles shot themselves in the foot with some fundamental errors leading to a 50% completion rate in the first part of the game in which they slumped to a 22-0 deficit, Hasler quipped he'd "like to have the first 20 minutes over again".

"They're the things we spoke about. Early in the game turning the ball over and just not in the game with that kind of discipline with the ball, basics and fundamentals about turning the ball over and controlling possession," he said.

"You give a side like Penrith a start like that, it's always going to be difficult."

The team picked the tempo up late in the first half in one of the few positives from the evening, holding an even share of the ball in the 15 minutes before half-time and scoring one try while going agonisingly close to a second.

"Right tempo at the back end of the first half, bit of ball, bit of set for set, get into an arm wrestle with them. Start to apply some pressure," Hasler said.

"We'll keep turning up and keep aiming up, that's all we can do."