South Sydney had the bye in round 13 to rest up after their big win over the Eels a week prior, while the Knights come into this one off a battering from those very same Eels.
Missing a stack of regular first-graders and with new half Jake Clifford on club debut, the Knights were off the pace from the get-go against a fired-up Parramatta, going down 40-4 on Old Boys' Day and quickly consigning an impressive round 12 win over Manly to the memory bank.
They may not get too many reinforcements this week but will be hopeful of having Origin prop Daniel Saifiti available, while Souths will be sweating on Damien Cook, Latrell Mitchell, Cameron Murray, Dane Gagai, Jai Arrow and Jaydn Su'A getting through Wednesday night without incident.
Souths will be hoping their two stumbles against the Panthers and Storm are put behind them and enter this clash in fourth place while the Knights drop to 14th with the Sharks and Raiders leapfrogging them thanks to bye points.
Match: Rabbitohs v Knights
Round 14 -
Venue: Stadium Australia, Sydney
Rabbitohs: Origin duo Damien Cook and Cameron Murray will be rested from the South Sydney team that will face Newcastle on Saturday.
Benji Marshall will slot in at hooker and Hame Sele is the new lock with Murray out. Liam Knight and rookie hooker Peter Mamouzelos join the interchange.
Jaydn Su'A and Latrell Mitchell will back up from the match in Townsville.
The Rabbitohs had already ruled out Maroons representatives Dane Gagai and Jai Arrow.
Josh Mansour and Tautau Moga dropped out of the extended squad 24 hours before kick-off.
The Rabbitohs have won 10 of their past 12 games against the Knights.
Knights: Connor Watson replaces Phoenix Crossland in the halves, Sauaso Sue starts at lock and Mitche Barnett moves to the bench. Matthew Croker joins the interchange.
Brayden Musgrove dropped out of the side on Friday and his place on the wing is taken by Dominic Young, who plays his second game of the season.
Blues prop Daniel Saifiti has been named to back up after getting through 50 minutes in Origin I.
An injury to Starford To'a will see Kurt Mann shift to the centres and Enari Tuala onto the wing.
Jirah Momoisea was the other player to drop out of the squad on Friday.
The Knights have won three of their past four games at Stadium Australia.
Fullback for Rabbitohs is number 1 Latrell MitchellFullback for Knights is number 1 Tex Hoy
Winger for Rabbitohs is number 2 Alex JohnstonWinger for Knights is number 2 Enari Tuala
Centre for Rabbitohs is number 3 Braidon BurnsCentre for Knights is number 3 Kurt Mann
Centre for Rabbitohs is number 4 Campbell GrahamCentre for Knights is number 4 Bradman Best
Winger for Rabbitohs is number 5 Taane MilneWinger for Knights is number 21 Dominic Young
Five-Eighth for Rabbitohs is number 6 Cody WalkerFive-Eighth for Knights is number 14 Connor Watson
Halfback for Rabbitohs is number 7 Adam ReynoldsHalfback for Knights is number 6 Jake Clifford
Prop for Rabbitohs is number 8 Mark NichollsProp for Knights is number 8 Jacob Saifiti
Hooker for Rabbitohs is number 14 Benji MarshallHooker for Knights is number 9 Jayden Brailey
Prop for Rabbitohs is number 10 Tevita TatolaProp for Knights is number 10 Daniel Saifiti
2nd Row for Rabbitohs is number 11 Keaon Koloamatangi2nd Row for Knights is number 11 Brodie Jones
2nd Row for Rabbitohs is number 12 Jacob Host2nd Row for Knights is number 12 Lachlan Fitzgibbon
Lock for Rabbitohs is number 16 Hame SeleLock for Knights is number 15 Sauaso Sue
Interchange for Rabbitohs is number 15 Jaydn Su'AInterchange for Knights is number 13 Mitchell Barnett
Interchange for Rabbitohs is number 17 Thomas BurgessInterchange for Knights is number 16 Josh King
Interchange for Rabbitohs is number 18 Liam KnightInterchange for Knights is number 17 Jack Johns
Interchange for Rabbitohs is number 23 Peter MamouzelosInterchange for Knights is number 20 Matt Croker
Reserve for Rabbitohs is number 20 Blake TaaffeReserve for Knights is number 18 Gehamat Shibasaki
- Referee: Chris Butler
- Touch Judge: Ziggy Przeklasa-Adamski
- Touch Judge: Mark Bohan
- Senior Review Official: Steve Chiddy
Damien Cook v Jayden Brailey: Assuming Cook backs up from Origin, which he usually does, the work of the two No.9s will be vital. Brailey has been a little quiet of late while Cook's form picked up just in time for Origin.
Cook had a try and a try assist in his last outing against the Eels having registering none of either since round four. Brailey still leads Cook in both departments so far this year with three tries to two and four assists to three.
Souths flyer Alex Johnston had a whopping six line breaks in his three-try last-start outing against the Eels (the most by any player in one game this year), taking him to 18 for the season - three clear of Josh Addo-Carr and Reuben Garrick in joint second place on 15.
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